GIP / GLP-1 dual receptor agonist
Compounded Tirzepatide
The next-generation GLP-1, with dual-action results that often exceed semaglutide for tolerant patients.
$299/mo — flat at every dose
Takes ~5 min · 100% online · Free to start
Tirzepatide is a dual GIP and GLP-1 receptor agonist that produces stronger average weight loss than semaglutide in head-to-head trials — average reductions of 20 to 22 percent of body weight over 72 weeks in clinical trials. Toned offers compounded tirzepatide prescribed by licensed clinicians, paired with lifestyle support.
Reviewed by the Toned editorial team · Last reviewed July 7, 2026
Education
What it is
Tirzepatide acts on two receptors at once: GIP (glucose-dependent insulinotropic polypeptide) and GLP-1. Tirzepatide is also the active ingredient in the brand-name medications Mounjaro and Zepbound; the compounded version is a separate product prepared by a state-licensed compounding pharmacy operating under Section 503A and is not FDA-approved.
How it works
Hitting both GIP and GLP-1 receptors gives tirzepatide stronger appetite suppression and metabolic effects than semaglutide. Patients start at a low dose and titrate every 4 weeks based on tolerance and response.
Who it's for
Adults with significant weight to lose, those who plateaued on semaglutide, or patients who want the strongest available evidence-based GLP-1. Same screening criteria as semaglutide.
What patients value
- 20 to 22% average weight loss over 72 weeks in clinical trials
- Dual GIP + GLP-1 mechanism
- Often more effective for plateaus on semaglutide
- Shipped from the same licensed compounding pharmacy network
Worth considering
- Side-effect profile similar to semaglutide; titration helps minimize
- Compounded tirzepatide is not FDA-approved as a finished product
- Higher upfront price than semaglutide
Considering Tirzepatide?
Share your health history online. A licensed provider will determine whether this protocol is appropriate for you.
Takes ~5 min · 100% online · No insurance needed
Compounded medications are not FDA-approved. All prescriptions require evaluation and approval by an independently licensed medical provider. Individual results vary.