Comparison
Semaglutide vs Tirzepatide
Semaglutide and tirzepatide are both injectable GLP-1 medications for weight loss. Tirzepatide acts on two receptors (GIP and GLP-1) and produces stronger average weight loss in head-to-head trials, while semaglutide has more long-term safety data. Both are available compounded through Toned by prescription.
Semaglutide Single GLP-1 receptor agonist | Tirzepatide Dual GIP + GLP-1 agonist | |
|---|---|---|
| Mechanism | GLP-1 agonist | GIP + GLP-1 dual agonist |
| Average weight loss (clinical trial) | ~15% | ~20-22% |
| Sold under brand names | Ozempic / Wegovy | Mounjaro / Zepbound |
| Dosing schedule | Weekly injection | Weekly injection |
| Long-term safety data | Strongest available | Strong, less long-term |
| Common side effects | Mild nausea, GI | Mild nausea, GI |
| Toned price (flat at every dose) | $149/mo | $299/mo |
| Compounded option available |
Which fits you
Two right answers, for different people.
Semaglutide
Best for first-time GLP-1 users, those prioritizing the strongest long-term safety record, and budget-conscious starters.
Tirzepatide
Best for higher weight loss goals, plateaus on semaglutide, or people seeking the most aggressive evidence-based protocol.
Questions
Fair questions. Straight answers.
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